Symbol
Name
ID

Tnfaip3
tumor necrosis factor, alpha-induced protein 3
MGI:1196377

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Lymphopenia	Colitis	Anterior uveitis	Skin rash	Antinuclear antibody positivity	Lupus anticoagulant
Disease(s) Associated with TNFAIP3
familial Behcet-like autoinflammatory syndrome

Mouse Phenotypes

immune system phenotype

decreased B cell apoptosis

increased B cell proliferation

increased susceptibility to induced colitis

intestinal inflammation

thymus atrophy

enlarged spleen

increased immature B cell number

abnormal myelopoiesis

myeloid hyperplasia

increased granulocyte number

abnormal B cell number

increased germinal center B cell number

decreased mature B cell number

decreased B-1a cell number

decreased B-1b cell number

decreased marginal zone B cell number

increased follicular B cell number

increased plasma cell number

decreased B cell number

increased B cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased effector memory T-helper cell number

increased T cell number

increased lymphocyte cell number

increased macrophage cell number

abnormal B cell morphology

abnormal B-1a B cell morphology

abnormal spleen morphology

increased splenocyte number

pale spleen

abnormal B cell activation

increased IgA level

increased IgG2a level

increased IgG level

increased IgM level

increased immunoglobulin level

increased microglial cell activation

abnormal circulating cytokine level

increased circulating interferon-gamma level

abnormal circulating interleukin level

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

enlarged lymph nodes

abnormal cytokine secretion

abnormal chemokine secretion

decreased interleukin-6 secretion

increased interleukin-6 secretion

increased susceptibility to autoimmune disorder

increased autoantibody level

increased anti-nuclear antigen antibody level

abnormal inflammatory response

increased inflammatory response

CNS inflammation

joint inflammation

liver inflammation

kidney inflammation

uterus inflammation

lung inflammation

Availability

Mouse Genotype

Tnfaip3^m1Apb/Tnfaip3^m1Apb

Tnfaip3^tm1.1Gho/Tnfaip3^tm1.1Gho

Tnfaip3^tm1Ama/Tnfaip3^tm1Ama

Tnfaip3^tm3.1Ama/Tnfaip3^tm3.1Ama

Tnfaip3^tm4.1Ama/Tnfaip3^tm4.1Ama

Cd19^tm1(cre)Cgn/Cd19⁺
Tnfaip3^tm1.1Awai/Tnfaip3^tm1.1Awai (conditional)

Tnfaip3^tm1.1Gvl/Tnfaip3^tm1.1Gvl
Tg(Vil1-cre)997Gum/0 (conditional)

Tnfaip3^tm1Homy/Tnfaip3^tm1Homy
Tg(Mx1-cre)1Cgn/? (conditional)

Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/?
Tnfaip3^tm1Homy/Tnfaip3^tm1Homy (conditional)

Tnfaip3^tm2Ama/Tnfaip3^tm2Ama
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Tnfaip3^tm2Ama/Tnfaip3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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